A unique case of bradycardia recognized by wearable technology as first presentation of complete heart block

Wearable technology has advanced significantly, and the proposed health benefits have been widely touted. Most of the discussion has been surrounding the identification and diagnosis of asymptomatic atrial fibrillation. However, the heart monitoring functions of the wearable technology can also identify other abnormalities as well. We present the first case of wearable technology identified bradycardia diagnosed as the primary presentation of complete heart block. Wearable technology has advanced significantly, but still poses questions regarding its use in screening for rare conditions. One remaining challenge is balancing the desire to screen for rare asymptomatic conditions without overburdening emergency departments with patients responding to alarms on their devices.     

经皮穴位电刺激联合颈丛神经阻滞麻醉在甲状腺手术中的应用研究

目的:观察经皮电刺激合谷、内关穴联合颈丛神经阻滞麻醉在甲状腺手术中的应用效果。方法:将68例行甲状腺手术的患者随机分为观察组和对照组各34例,对照组采用颈丛神经阻滞麻醉,观察组采用经皮电刺激合谷、内关穴联合颈丛神经阻滞麻醉。比较两组麻醉前后平均动脉压和血氧饱和度,以及两组术后麻醉效果、疼痛数字量表(NRS)评分和不良反应情况。结果:两组麻醉后各时点平均动脉压较麻醉前均升高,差异有统计学意义(P<0.05);观察组手术全程血压变化幅度小于对照组,差异有统计学意义(P<0.05)。观察组麻醉前后血氧饱和度无明显变化,差异无统计学意义(P>0.05);对照组麻醉后血氧饱和度低于麻醉前,差异有统计学意义(P<0.05)。两组患者全部麻醉成功,但对照组Ⅲ级麻醉患者比例高于观察组,差异有统计学意义(P=0.001)。观察组术后1 h、4 h、12 h的NRS评分均低于对照组,差异有统计学意义(P<0.001)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.031)。结论:在甲状腺手术中采用经皮穴位电刺激联合颈丛神经阻滞麻醉,具有麻醉效果好、循环干扰小、并发症少等优点。     

BIA-ALCL diagnosis on CytoLyt fixed ThinPrep,cell block and immunohistochemistry

Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is an emergent rare T cell non-Hodgkin lymphoma arising in association with a breast implant, particularly textured ones. Recent guidelines list cytopathological examination as the first essential step for diagnosis, routinely followed by CD30 immunohistochemistry (IHC) and flow cytometry (FC) for a T cell clone. The majority of BIA-ALCL literature regarding cytopathological evaluation describes morphology based on various preparation methods limited to cytospins and smears with the exception of at least one case report detailing cytomorphological and IHC findings on ThinPrep. This case report details initial diagnosis of BIA-ALCL rendered with CytoLyt prepared ThinPrep and cell block, including the specific antibodies used for IHC. The ThinPrep slide showed numerous singly dispersed large, atypical cells with abundant cytoplasm containing irregular nuclei with dispersed chromatin and prominent nucleoli in a background of macrophages, inflammatory cells and granular debris. TIA-1 and CD30 along with other T-cell markers, including specific antibodies, remains immunoreactive in tissue collected in CytoLyt solution. Cell size reduction, artifactual lymphoid cell aggregation and prominent nucleoli in benign and reactive conditions are among other ThinPrep cellular alterations pathologists should bear in mind.     

丹参饮合温胆汤加减对稳定型心绞痛患者心肌缺血的保护机制

目的:观察丹参饮合温胆汤加减治疗痰瘀阻滞型稳定型心绞痛(SAP)的疗效及对心肌缺血的保护机制研究。方法:将132例患者随机按数字表法分为对照组和观察组各66例。除去脱落、失访和剔除病例,两组最后分别完成63例。所有患者进行抗心绞痛药物和控制风险因素药物治疗。对照组口服丹蒌片,5片/次,3次/d;观察组给予丹参饮合温胆汤加减,1剂/d;两组疗程均为治疗3个月。每周进行心绞痛发作情况评分;冠心病心肌缺血情况采用心电图平板运动试验评价,中医症状和生活质量分别进行痰瘀阻滞证、西雅图心绞痛量表(SAQ)评分,血液流变学指标、白细胞介素-6(IL-6),肿瘤坏死因子-α(TNF-α),细胞间黏附分子-1(ICAM-1),胱抑素C(CysC),同型半胱氨酸(Hcy),缺血修饰白蛋白(IMA)和巨噬细胞移动抑制因子(MIF)水平,均治疗前后各评价1次;并进行安全性评价。结果:观察组心绞痛发作次数、持续时间、疼痛程度和硝酸甘油用量评分均低于对照组(P<0.01);观察组Duke评分、总运动时间、出现ST段压低1.0 mm的时间、心绞痛出现时间和代谢当量均多于对照组(P<0.01);观察组SAQ评分高于对照组(P<0.01),痰瘀阻滞证积分低于对照组(P<0.01);观察组心绞痛疗效优于对照组(Z=2.091,P<0.05);观察组ICAM-1,CysC,IL-6,TNF-α水平均低于对照组(P<0.01);观察组全血黏度(低切、高切)、全血还原黏度、血浆黏度、血小板聚集率、纤维蛋白原(FIB)均低于对照组(P<0.01);观察组IMA,Hcy和MIF水平均低于对照组(P<0.01)。没有发现服用丹参饮合温胆汤相关不良反应。结论:在西医常规治疗的基础上,丹参饮合温胆汤加减治疗SAP,可控制心绞痛发作,减轻痰瘀阻滞证症状,提高生活质量,有着较好临床疗效,且安全,并能改善患者血液流变性,抑制炎症反应,减轻管腔狭窄或阻塞,从而改善心肌缺血程度。     

Ureteroscopic lithotripsy combined with paravertebral block anesthesia or general anesthesia: A propensity matched case–control study

BackgroundTo evaluate the safety, efficacy and cost of paravertebral block anesthesia for ureteral stones patients undergoing ureteroscopic lithotripsy.MethodsFour hundred and eighty-two patients who underwent ureteroscopy for unilateral ureteral stones were incorporated into our retrospective study. A propensity-matched comparison in patients with paravertebral nerve block anesthesia (PVB) group and general anesthesia (GA) group was performed. Intraoperative hemodynamic parameters, operative time, visual analog scale for pain, stone-free rate, anesthetic cost and postoperative hospital stay were compared between the two groups.ResultsSixty-one GA cases were propensity matched to 61 PVB cases. In the PVB group, all the procedures were completed successfully without anesthesia conversion. Significantly less intraoperative severe hypotensive (P = 0.002) and arrhythmia (P < 0.001) episodes in PVB group. There were no significant differences in operative time (p = 0.702), initial stone-free rate (p = 0.686), and total stone-free rate (p = 0.794) between the two groups. The PVB group had lower postoperative pain and prolonged analgesia (p = 0.007). The postoperative hospital stay in the PVB group was significantly shorter (3.20 ± 0.73 vs 3.84 ± 1.32 d, p = 0.001). And the cost of anesthesia was lower in the PVB group (195.47 ± 13.01 vs 396.31 ± 36.45 US dollars, p < 0.001).ConclusionUnder PVB anesthesia, URS can be successfully completed without anesthetic transformation, and its efficacy and safety have been demonstrated. When economic aspects are taken into consideration, PVB seems to be a more economical and effective anesthetic method of URS.     

超声引导下单次竖脊肌平面阻滞对单侧乳腺癌根治术后患者恢复的影响

目的探讨超声引导下单次竖脊肌平面(ESP)阻滞对单侧乳腺癌根治术后患者恢复的影响。方法依据随机数字表法将60例行单侧乳腺癌根治术的女性乳腺癌患者分为观察组和对照组,每组30例。麻醉诱导前两组患者均采用超声引导下患侧ESP阻滞,观察组患者给予0.5%盐酸罗哌卡因20 ml,对照组患者给予等量的生理盐水。两组患者均采用全凭静脉麻醉进行诱导和维持,术中采用喉罩通气,术后采用静脉自控镇痛。比较两组患者术后苏醒即刻及术后2、6、12、24、48 h的视觉模拟评分法(VAS)评分,比较两组患者术后镇痛泵按压次数、镇痛药吗啡的用量及术后并发症发生情况。结果术后苏醒即刻及术后2、6、12、24、48 h,观察组患者的VAS评分均明显低于对照组(P﹤0.01)。观察组患者术后镇痛泵按压次数和吗啡用量均明显低于对照组(P﹤0.01)。观察组患者术后恶心呕吐和皮肤瘙痒的发生率均低于对照组(P﹤0.05)。结论超声引导下单次ESP阻滞可以缓解单侧乳腺癌根治术后患者的急性疼痛,降低术后相关并发症发生率,促进患者术后恢复。     

Winograd surgery can be performed under partial digital block in patients with ingrown toenails

BackgroundWinograd procedures performed under a partial digital block with a single needle to the surgical side instead of the entire toe were not evaluated. This study aimed to examine the clinical results of classic ring block and partial digital block performed during Winograd procedures in cases of ingrown toenails.MethodsA total of 210 patients underwent Winograd surgery were divided into two groups according to the type of anesthesia used as follows: traditional ring block (TRB) and partial digital block (PDB). Visual analog scale (VAS) scores, Heifetz stage patient satisfaction levels, recurrence rates, and need for reoperation were recorded.ResultsCompared with the PDB group, the during operation VAS score was statistically significantly higher in the TRB group (p = 0001). There was no statistically significant difference between the groups in terms of postoperative satisfaction, recurrence (p = 0294), and reoperation rates (p = 0651).ConclusionsThis study is the first to show that adequate anesthetic efficacy can be achieved with a less invasive intervention for Winograd procedures.